Medicinal Chemistry Team Four
Team Leader: Dr Swen Hoelder
Location: Haddow Laboratories, Sutton
Section: Cancer Research UK Cancer Therapeutics Unit
Research in Medicinal Chemistry Team 4 is focussed on applying our organic chemistry skills to cancer drug discovery programs. Drug discovery is a highly interdisciplinary task and The Institute of Cancer Research provides a unique environment for pursuing close collaborations with other departments namely biologists and pharmacologists.
We are particularly interested in pursuing novel and previously unexplored therapeutic targets. Inhibitors, which we identify by creative design and synthesis of novel heterocyclic scaffolds or by high-throughput screening, are invaluable tools for the validation of these novel targets as genuine cancer targets.
As a medicinal chemistry team working on discovery projects we place emphasis on structure-based design in the determination of our synthetic targets. In addition, we utilise several other state-of-the-art technologies including: parallel synthesis techniques, computer modelling, crystallography and fragment based approaches.
Besides being involved in drug discovery programs we also endeavour to support the identification of new oncology targets through chemical biology approaches. We are interested in the synthesis of natural products derived inhibitors of cancer targets. Moreover, we are keen to explore and further develop synthetic methodologies as well as computational chemistry techniques.
Aim
- Discovery and development of innovative small molecule cancer therapeutics
In the Cancer Research UK Cancer Therapeutics Unit
