Signal Transduction and Molecular Pharmacology Team
Team Leader: Professor Paul Workman
Location: Haddow Laboratories, Sutton
Section: Cancer Research UK Cancer Therapeutics Unit
This Team has two major complementary roles:
- To understand the molecular mechanism of action of drugs that affect, or are affected by, signal transduction pathways that regulate proliferation, cell cycle and survival in cancer cells
- To discover and develop innovative new drugs that act on novel molecular targets, defined by the genomics and molecular pathology of cancer.
The Team is particularly involved in the development of inhibitors of the heat shock protein 90 molecular chaperone, PI3 kinase and cyclin-dependent kinases. In addition we are interested in applying gene expression microarray and RNAi technology to understand the cellular pharmacology of molecular therapeutics and the discovery of biomarkers of drug effect.
In the Cancer Research UK Cancer Therapeutics Unit
